If by boosted you mean turbo'd, then yes, there is more work required with the V6, than with a 4cyl, because there isn't anything really designed for a turbo application for the V6.
There are plenty of S/C'd V6's, whereas, you won't find many S/C'd 4cyl.
Alot of guys have parted out the S/C'd setups because they are getting out of the Accord game, however, with the builds that are being done either through NVA-AV6, or individually, S/C setups are making a slow comeback, especially with the M90 setup over the Comptech option.