Is V6 engine more likely to break down earlier than a V4?

[xci.ed6]

Really, I check the fluids, use honda specific, and change them when they need it, same with filters.

 

[NibX18]

Never been around V4 engines... I wouldn't know

 

[2000BlackCoupe]

i got 25 miles a gallon from my last fill up, but now im at 160 miles and a little less than half a tank left. i didnt have an o2 sensor for the 25 mpg, but now i have one and its gone down a lot

 

[xci.ed6]

Never been around V4 engines... I wouldn't know

Actually, rode a few Interceptors, V4 Honda's. Round pistons.