Not really, people are afraid of what they don't know... any big power turbo car is going to have high compression..
Did a 10.5:1 B series making 570 on pump gass
Did a 11:1 B series making 700+ racegas
Did a 10.5:1 ish H making 475 on stock head pump gas...
Its all in the tune my friend, If you have a good tuner, and good setup you'll be fine.